Age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded
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چکیده
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منابع مشابه
Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded.
BACKGROUND D-dimer testing to rule out deep vein thrombosis is less useful in older patients because of a lower specificity. An age-adjusted D-dimer cut-off value increased the proportion of older patients (>50 years) in whom pulmonary embolism could be excluded. We retrospectively validated the efficacy of this cut-off combined with clinical probability for the exclusion of deep vein thrombosi...
متن کاملValidation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis OPEN ACCESS
Objective To determine whether the use of age adapted D-dimer cut-off values can be translated to primary care patients who are suspected of deep vein thrombosis. Design Retrospective, cross sectional diagnostic study. Setting 110 primary care doctors affiliated with three hospitals in the Netherlands. Participants 1374 consecutive patients (936 (68.1%) aged >50 years) with clinically suspected...
متن کاملValidation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis
OBJECTIVE To determine whether the use of age adapted D-dimer cut-off values can be translated to primary care patients who are suspected of deep vein thrombosis. DESIGN Retrospective, cross sectional diagnostic study. SETTING 110 primary care doctors affiliated with three hospitals in the Netherlands. PARTICIPANTS 1374 consecutive patients (936 (68.1%) aged >50 years) with clinically sus...
متن کاملThe use of age-dependent D-dimer cut-off values to exclude deep vein thrombosis. Reply to "Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded". Haematologica 2012;97(10):1507-13.
Following on from recent studies which suggest in patients over 50 years of age an age-dependent D-dimer cut off of ‘age multiplied by 10’, in conjunction with a non-high clinical probability, can be used to safely exclude pulmonary embolism (PE), we read with interest the application of the same age-dependent D-dimer cut off to the exclusion of deep vein thrombosis (DVT) by Douma et al. Their ...
متن کاملAge-adjustment of the D-dimer cut-off value to improve the exclusion of thromboembolic events in older patients
In 2010, Douma et al introduced a formula to adjust D-dimer cut-off values for age in outpatients >50 years: Age × 0.01 mg/L. Application of this approach in different retrospective cohorts confirmed that age adjustment increases specificity while hardly affecting sensitivity. Reducing the false positive results, the ageadjusted D-dimer cut-off point raises the proportion of older patients in w...
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